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. 2017 Aug 3;12(8):e0182698. doi: 10.1371/journal.pone.0182698

Fig 1. Dose-dependent systemic effects in Sprague Dawley rats 1 h and 1 week after injection of vehicle or ZL006 (5, 10, 50 mg/kg).

Fig 1

A: Locomotion during a 5-min Open Field session. After 1 h, animals receiving 50 mg/kg ZL006 moved significantly less compared with those treated with vehicle. After 1 week, this effect was present in all ZL006-injected rats; #: p ≤ .05 compared with respective vehicle; n = 6–8/group. B: Immobility during a 5-min Forced Swim Test session. There were no significant strain or treatment effects, p’s > .05; n = 6–8/group. Values are expressed as means ± SEM and were analyzed using one-way ANOVAs followed by Bonferroni post-hoc tests.