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. 2017 Aug 3;12(8):e0182698. doi: 10.1371/journal.pone.0182698

Fig 2. Acute systemic effects in Flinders Sensitive/Resistant Line rats 1 h after injection of vehicle or ZL006 (15 mg/kg (B); 15–50 mg/kg (C)).

Fig 2

A: Locomotion during a 5-min Open Field session. A significant strain difference indicated that FSL rats moved a greater total distance than FRL rats; **: p ≤ .005; n = 7/group. B: Immobility during a 5-min Forced Swim Test session. A significant strain difference indicated that FSL rats were more immobile than FRL rats; ***: p ≤ .001; n = 7/group. C: Replication of B with the inclusion of an additional dose (50 mg/kg). A significant strain difference indicated that FSL rats were more immobile than FRL rats; ***: p ≤ .001; n = 6–8. Values represent means ± SEM and were analyzed using two-way ANOVAs followed by pairwise comparisons.