TIME Cell Vessels Are Not Hampered by CAR-CIK Cells
(A) Representative 5× and 10× magnifications of TIME cell vessels after a 4 hr culture on Matrigel (TIME cells alone) or with NO DNA and CAR-CIK cells (WT CAR and CAM-L), respectively. (B) Analysis of TIME cell branching point number, alone or after a 4 hr co-culture with unmanipulated and CAR-CIK cells, as a measure of TIME cell tissue integrity and vessel spreading. Data represented are the result of mean ± SEM. n = 3 (***p < 0.001; one-way ANOVA, Bonferroni test).