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. 2017 May 6;25(8):1959–1973. doi: 10.1016/j.ymthe.2017.04.016

Figure 4.

Figure 4

Downregulation of HOXD-AS1 Suppresses Tumorigenicity and Chemo-Resistance of Prostate Cancer Cells In Vivo

(A) Construction of HOXD-AS1 stable knockdown PC-3 cells. The results are presented as the means ± SD of values obtained in three independent experiments. (B) The volume of tumors was measured every 3 days. The arrows indicate the time of PBS or paclitaxel administration. The results are presented as the means ± SD of values (n = 5). (C) The weight of tumors was measured after the tumors were surgically dissected. The results are presented as the means ± SD of values (n = 5). (D) Images of surgically dissected tumors of each group. (E) The expression of Ki67 in the tumor was examined by IHC. (F) The apoptosis in the tumor was detected by TUNEL assay. The scale bars in IHC and TUNEL images represent 50 μm. The histograms showed the score of IHC and proportion of TUNEL-positive cells in each group. The percentage in the histograms indicates the decreased or increased percentage in the PTX group compared with the PBS group. *p < 0.05; **p < 0.01.