Table 1. Characteristics of study groups.
| Categories | Controls | Validation cohort | Group A Post-surgical inflammation |
Group B Sepsis and septic shock |
P-value Group A vs. B* |
|---|---|---|---|---|---|
| Patients, n | 10 | 9 | 20 | 20 | N/A |
| Age, years | 60 (49–65) | 68 (58–74) | 62 (47–72) | 60 (53–67) | ns |
| Male/ female, n (%) | 8/2 (80/20) | 5/4 (55/45) | 10/10 (50/50) | 9/11 (45/55) | ns |
| #SOFA | N/A | 11 (8–13) | 4 (3–5) | 9 (7–11) | < 0.01 |
| #SAPS II | N/A | 37 (31–47) | 24 (17–28) | 32 (27–42) | < 0.01 |
| Death 28d, n (%) | N/A | 2 (22) | 0 (0) | 2 (10) | ns |
| #CRP [mg/L] | 5 (5–5) | 129 (102–250) | 76 (17–109) | 183 (143–270) | < 0.01 |
| #PCT [μg/L] | N/A | 1.17 (0.64–8.80) | 0.28 (0.11–1.33) | 3.22 (1.26–7.89) | < 0.01 |
| #IL-6 [ng/L] | N/A | 189 (96–336) | 84 (23–195) | 308 (85–1080) | < 0.01 |
| #Leucocytes x109/L | 6.6 (6.1–8.5) | 12.0 (8.5–13.5) | 13.4 (10.8–15.9) | 14.1 (8.0–18.3) | ns |
SOFA: Sequential organ failure assessment score; SAPS: Simplified Acute Physiology Score II; CRP: C-reactive protein, PCT: procalcitonin, IL-6: interleukin-6, N/A: not applicable, ns: not significant.
# median (interquartile range, IQR)
* non-parametric Mann-Whitney U test