Table 2. Top 5 canonical pathways identified by IPA *.
| Gene Network | P-value | DEGs (Overlap) | Differentially Expressed Genes | Cellular Functions |
|---|---|---|---|---|
| Insulin/IGF/PI3K/Akt Signaling | 5.50E-04 | 9/128 (7.0%) | ATF2, CALM1, HRAS, PPP3CB, RAC1, RAF1, RELA, ITPR2, PLEKHA4 | calcium signaling, cell cycle, cell senescence, apoptosis, immune response |
| Cell Cycle | 1.16E-03 | 9/142 (6.3%) | ARID1A, BARD1, HDAC3, HRAS, MRE11A, POLR2C,, HDAC7, RAD51, UBD | tumor suppression, transcription, cell growth, apoptosis (p53), DNA repair |
| Nerve Growth Factor Signaling | 1.33E-03 | 8/117 (6.8%) | ATF2, HRAS, RAF1, RAP1A, RELA, RPS6KB2, SMPD4 | GTPase activity, cell cycle, senescence, proliferation, apoptosis |
| Cholesterol Biosynthesis I and II (24,25-dihydrolanosterol) | 1.48E-03 | 3/13 (23.1%) | FDFT1, LSS, HSD17B7 | mevalonate pathway, cholesterol biosynthesis, squalene biosynthesis, protein prenylation |
* Bold Italics = Upregulated Genes. Light Italics = Downregulated genes.
IPA analysis of 455 DEGs (p < 0.01).