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. 2017 Aug 3;12(8):e0181308. doi: 10.1371/journal.pone.0181308

Table 4. IPA analysis identifies 5 upstream regulators related to differentially expressed genes (DEGs).

Upstream Regulator P-value Functional pathways
Tumor Repressor Protein 53 (TP53) 9.90E-05 response to cellular stress, cell cycle arrest, apoptosis, senescence, DNA repair
Cystatin D (CST5) 2.74E-04 inhibits lysosomal and secreted cysteine proteases, transcriptional regulation, cytokine secretion
Monoacylglyerol O-acyltransferase 1 (MOGAT1) 8.39E-04 diacylglycerol synthesis, triglyceride synthesis
POU class 2 homeobox 1 (POU2F1) 9.83E-04 transcriptional regulator, T-cell differentiation
C-X-C motif chemokine ligand 12 (CXCL12) 1.49E-03 inflammatory response, leukocyte chemotaxis