Table 5. Ingenuity pathway analysis top 10 up-regulated genes.
| Gene Symbol | Name/Product | Functional Role** | Fold Change (Int/Tol)* | Nominal P Value = * |
|---|---|---|---|---|
| HECTD2-AS1 | HECTD2 antisense RNA 1 (Gene ID 100188947) |
Inflammatory response | 14.78 | 0.0961 |
| UCP3 | Uncoupling Protein 3 (Gene ID 7352) |
Muscle energy metabolism, mitochondrial function, protection from oxidative stress | 11.61 | 0.0090 |
| ALDOA | Aldolase, fructose-bisphosphate A (Gene ID 226) |
Mediates glycolysis, myopathy | 10.21 | 0.0096 |
| C20orf194 | Chromosome 20 open reading frame 194 (Gene ID 25943) | Unknown | 9.91 | 0.0018 |
| HOMER3 | Homer scaffolding protein 3 (Gene ID 9454) |
Neuronal signaling, T-cell activation, trafficking of amyloid beta peptides. | 8.28 | 0.0002 |
| DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A (Gene ID 1859) |
Cell proliferation, brain development | 8.05 | 0.0038 |
| SPATS2L | Spermatogenesis associated serine rich 2 like (Gene ID 26010) | Response to oxidative stress. Ribosomal biogenesis | 7.67 | 0.0006 |
| CEP85 | Centrosome protein 85 (Gene ID 64793) |
Cell cycle progression (aka CCDC21) | 7.31 | 0.0023 |
| ZBED1 | Zinc finger BED-type containing 1 (Gene ID 9189) |
Transcriptional regulator related to cell proliferation | 6.11 | 0.0003 |
| ANXA3 | annexing A3 (Gene ID 306) | Signal transduction, cellular growth | 5.94 | 0.0011 |
* P values calculated by linear regression analysis with adjustment for vitamin D levels.
** Functional role derived from NCBI Protein and Unigene entries.