Table 6. Ingenuity pathway analysis top 10 down-regulated genes.
| Gene Symbol |
Name/Product | Functional Role** | Fold Change (Int/Tol) | Nominal P Value = * |
|---|---|---|---|---|
| MFF | Mitochondrial fission factor (Gene ID 56947) |
Mitochondrial and peroxisomal fission, |
- 100.00 | 0.0040 |
| HLA-DRB6 | Major histocompatibility complex, class II, DR beta 6 (pseudo gene) (Gene ID 3128) |
Antigen processing, autoimmunity |
-37.04 | 0.0036 |
| NNMT | N-myristoyltransferase 1 (Gene ID 4836) |
Protein modification (N-myristoylation), G-protein activation | -13.89 | 0.0009 |
| CXCL9 | C-X-C motif chemokine ligand 9 (Gene ID 4283) |
T-cell trafficking, lymphocyte chemo attractant | -12.66 | < 0.0001 |
| GBP2 | Guanylate binding protein 2 (Gene ID 2634) |
GTPase, immunologic response | -10.99 | 0.0037 |
| CFH | Complement factor H (Gene ID: 3075) |
Complement activation, innate immunity | -10.53 | 0.0096 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 (Gene ID 7076) |
Inhibits matrix metalloproteinases (MMPs), inhibit apoptosis, muscle growth and remodeling | -7.58 | 0.0097 |
| LRRFIP1 | LRR binding FLII interacting protein 1 (Gene ID 9208) | Mitogenesis | -6.85 | < 0.0001 |
| GVINP1 | GTPase, very large interferon inducible pseudo gene 1 (Gene ID 387751) |
Innate and adaptive cellular immunity | -6.45 | 0.0050 |
| NBPF8 | Neuroblastoma breakpoint family member 8 (Gene ID 284565) | Neuronal development | -5.99 | 0.0028 |
* P values calculated by linear regression analysis with adjustment for vitamin D levels.
** Functional role derived from NCBI Protein and Unigene entries.