Table 7. Functional annotation clustering of DEGs seen in the muscle of patients experiencing statin myalgia (DAVID functional annotation clustering).
| Process | Number of genes | P = * | FDR# |
|---|---|---|---|
| Annotation Cluster 1: Protein catabolism (Enrichment Score 6.89) | |||
| Proteolysis involved in protein catabolic process | 37 | 1.8E-5 | 1.9E-5 |
| Cellular protein catabolic process | 37 | 1.0E-5 | 2.2E-5 |
| Protein catabolic process | 37 | 1.5E-5 | 4.8E-5 |
| Modification-dependent protein catabolic process | 35 | 1.6E-5 | 6.9E-5 |
| Ubi conjugation pathway | 31 | 1.2E-5 | 1.4E-4 |
| Cellular macromolecule catabolic process | 39 | 5.0E-5 | 2.6E-4 |
| Proteolysis | 42 | 1.8E-2 | 1.3E-1 |
| Annotation Cluster 2: Protein Ubiquitination (Enrichment Score 3.98) | |||
| Small conjugating protein ligase activity | 14 | 1.2E-2 | 3.7E-2 |
| Ubiquitin-protein ligase activity | 13 | 8.4E-3 | 5.0E-2 |
| Acid-amino acid ligase activity | 14 | 2.9E-2 | 2.6E-1 |
| Annotation Cluster 3: Nuclear and Organelle Proteins (Enrichment Score 3.91) | |||
| Nuclear lumen | 51 | 4.5E-3 | 2.0E-2 |
| Organelle lumen | 56 | 2.0E-2 | 2.7E-1 |
| Intracellular organelle lumen | 55 | 1.6E-2 | 2.8E-1 |
| Membrane enclosed lumen | 56 | 2.0E-2 | 4.5E-1 |
Functional clustering of 391 DEGs using DAVID Bioinformatics Resource (Version 6.7) accessed 9/28/2016 (https://david.ncifcrf.gov).
* P value adjusted for multiple comparisons (Benjamini-Hochberg).
#FDR = False Discovery Rate