Table 8. Observed versus expected minor allele frequency for gene polymorphisms associated with statin myalgia in cases versus controls compared to population frequency.
| Gene | SNP ID (Major/minor allele) |
Cases MAF§ (N = 12) |
Controls MAF (N = 7) |
Expected MAF ∞ HAP MAP (CEU) (N = 90) |
Nominal P* |
|---|---|---|---|---|---|
| SLCO1B1 | rs4149056 (C/T) | 0.33 | 0.00 | 0.15 | 0.039 |
| rs2306283 (C/T) | 0.83 | 0.43 | 0.39 | 0.170 | |
| SLCO2B1 | rs12422149 (G/A) | 0.51 | 0.08 | 0.09 | 0.01 |
| ABCC1 | rs4148330 (A/G) | 0.92 | 0.71 | 0.33 | 0.313 |
| ABCB1 | rs1128503 (C/T) | 0.67 | 0.43 | 0.45 | 0.268 |
| CoQ2 | rs4693075 (C/G) | 0.67 | 0.71 | 0.34 | 0.832 |
| RYR2 | rs2819742 (A/G) | 1.00 | 0.57 | 0.40 | 0.016 |
| HTR3B | rs2276307 (A/G) | 0.42 | 0.43 | 0.23 | 0.960 |
| HTR7 | rs1935349 (A/G) | 0.17 | 0.29 | 0.12 | 0.832 |
| rs1176744 (G/T) | 0.50 | 0.57 | 0.25 | 0.908 | |
| GATM | rs2453533 (A/C) | 0.33 | 0.71 | 0.29 | 0.131 |
| rs1145086 (A/C/G/T) | 0.33 | 0.71 | 0.33 | 0.131 |
Data are risk allele frequency (%) for SNPs previously associated with statin myalgia and myositis in case control and population studies. MAF is shown for cases and controls along with expected frequency in a population representative of the cohort. Risk Allele is shown in Bold. Differences in allele frequency between cases vs controls were assessed using Chi Square analysis. Nominal P values (Pearson) are provided.
§ MAF = minor allele frequency.
∞ Expected minor allele frequency in a European population (HAP-MAP CEU)
* difference in minor allele frequency between cases and controls was assessed by Student T-Test (unadjusted). Nominal p values are presented.