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. 2017 Aug 3;12(8):e0182435. doi: 10.1371/journal.pone.0182435

Fig 1. Geometric mean ratios of fibrinogen, PAI-1, and CRP in relation to urine arsenic in the SHS main cohort by diabetes status.

Fig 1

Lines represent the geometric mean ratio (GMR) of baseline fibrinogen (left panel), PAI-1 at Visit 2 (center panel), or CRP at Visit 2 (right panel), by log-transformed urine arsenic concentrations (ΣAs, μg/g creatinine), with the 10th percentile (3.6 μg/g creatinine) as the reference. The GMR of baseline fibrinogen concentrations are from a linear mixed model and the GMR of Visit 2 PAI-1, and CRP concentrations are from a linear regression (see statistical methods for details). Arsenic was modeled using restricted quadratic splines of log-transformed urine arsenic (knots at the 10th, 50th, 90th percentiles; 3.6, 8.4, and 22.4 μg/g creatinine, respectively). Models were fully-adjusted for all potential confounders in Model 2 (age, sex, education (no, some, or finished high school), smoking (never, former, current), alcohol drinking (never, former, current), BMI (kg/m2), LDL cholesterol (mg/dL), hypertension (yes/no), eGFR (mL/min/1.73 m2), and study center (AZ, OK, ND/SD).