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. 2001 Jul 24;98(16):9371–9376. doi: 10.1073/pnas.161191698

Figure 6.

Figure 6

Enhanced endogenous cannabinoid levels and activity in FAAH−/− mice. (A) FAAH−/− mice (filled column) possessed greatly increased endogenous brain levels of anandamide relative to FAAH+/+ mice (open bar); FAAH+/+, 50 ± 10 pmol/g of tissue; FAAH−/−, 775 ± 113 pmol/g of tissue; ***, P < 0.001 for FAAH−/− versus FAAH+/+ mice (planned comparison); n = 7–8 mice per group. (B) The prolonged response latency of FAAH−/− mice in the hot plate assay (Left, filled bar) was reversed by treatment with SR141716A (Right, filled bar). Vehicle administration failed to significantly affect the response latencies of FAAH−/−, FAAH+/−, and FAAH+/+ mice (Right, open bars), and SR141716A failed to significantly affect the response latencies of FAAH+/− and FAAH+/+ mice (Right, filled bars). n = 8–11 mice per group, assayed 30 min posttreatment. **, P ≤ 0.01 for SR141716A-treated FAAH−/− mice versus either vehicle-treated FAAH−/− mice or baseline latencies (planned comparison); ***, P < 0.005, for FAAH−/− versus FAAH+/− or FAAH+/+ mice (planned comparison). The results are presented as means ± SE.