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ED50 values for the behavioral effects of THC in FAAH+/+ and FAAH−/− mice [mg/kg (95% confidence limits)]
| Hypomotility | Antinociception | Hypothermia | |
|---|---|---|---|
| FAAH+/+ | 13 (10–17) | 13 (7–26) | 12 (9–17) |
| FAAH−/− | 13 (9–18) | 12 (7–20) | 15 (10–24) |
FAAH+/+ and FAAH−/− mice were injected with 5, 10, 20, or 40 mg/kg THC (i.p.) and tested as described in Materials and Methods. The highest dose of THC failed to elicit more than 50% catalepsy in either genotype. n = 6–8 mice per group.
