Table 3.
Cox proportional hazard analysis for HF events
| Univariate HR (95% CI) | P value | Multivariate HR (95% CI) | P value | |
|---|---|---|---|---|
| Age (years) | 1.00 (0.97–1.03) | 0.78 | Not selected | |
| Sex (male) | 0.90 (0.45–1.80) | 0.77 | Not selected | |
| MMP‐9 (>23.2 ng/mL) | 2.57 (1.29–5.12) | 0.007 | 3.73 (1.03–13.46) | 0.043 |
| TIMP‐1 (>171.5 ng/mL) | 2.02 (0.97–4.20) | 0.05 | Not selected | |
| Taking a CCB | 0.48 (0.23–1.01) | 0.05 | Not selected | |
| BNP (>210 pg/mL) | 2.83 (1.43–5.62) | 0.025 | Not selected | |
| NA (>0.38 ng/mL) | 2.44 (0.87–6.81) | 0.08 | Not selected | |
| IL‐6 (>7.5 pg/mL) | 2.47 (1.25–4.86) | 0.009 | Not selected | |
| TNF‐alpha (>0.73 pg/mL) | 1.21 (0.56–2.58) | 0.62 | Not selected | |
| EF (>47.4%) | 3.50 (1.59–7.67) | 0.002 | Not selected |
BNP, brain natriuretic peptide; CCB, calcium channel blocker; CI, confidence interval; HF, heart failure; HR, hazard ratio; MMP, matrix metalloproteinase; NA, noradrenaline; TIMP, tissue inhibitor of MMP; TNF, tumor necrosis factor.