Figure 4.

Short-Term Transgene Activity or Presence in the Monkey Plasma

(A and B) Stable reporter gene hSEAP activity (A) and hFIX expression (B) in monkey plasma over time in animals cross-administered with AAV5^ch-hSEAP followed by AAV1-hFX and in animals injected with AAV5^ch-hFIX or AAV1-hFIX only. Monkeys were injected i.v. at day 0 with an AAV5^ch-based vector (AAV5^ch-hSEAP) or PBS and on day 30 with either an AAV1- or AAV5^ch-based vector (AAV1-hFIX or AAV5^ch-hFIX) or PBS. RLU, relative luminescence units. Data are presented as means ± SEM of all monkeys in each experimental group.