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. 2017 Aug 3;121(4):354–367. doi: 10.1161/CIRCRESAHA.116.310529

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© 2017 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — MicroRNA-146a (miR-146a) is expressed in murine atherosclerotic plaques. A, Cross-sections of Ldlr^−/− or Ldlr^−/−;miR-146a^−/− mouse aortic roots after 18 wk of high cholesterol diet (HCD). Expression of miR-146a, assessed by in situ polymerase chain reaction (red) overlaps with Mac-2–positive macrophages (purple) and CD31-positive endothelial cells (ECs; green) in the intima, and signal is absent in miR-146a^−/− mice. miR-146a expression during the progression of atherosclerosis is shown in Online Figure I. B, Schematic of the aorta, indicating the aortic root (examined in A), the greater curvature (GC, atheroprotective) and lesser curvature (LC, atherosusceptible) of the aortic arch and the descending thoracic aorta (DTA, atheroprotective). C, Expression of miR-146a (normalized to U6 levels) in the specified regions of the aorta in Ldlr^−/− mice after 4 wk of HCD (n=5). Ldlr indicates low-density lipoprotein receptor.