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. 2017 Aug 3;121(4):354–367. doi: 10.1161/CIRCRESAHA.116.310529

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© 2017 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — Global loss of microRNA-146a (miR-146a) inhibits bone marrow (BM) hematopoiesis and promotes extramedullary hematopoiesis in the spleen. Increase of splenic (A) and decrease in BM (B) CD45⁺ leukocytes and Ly6G⁻/CD115⁻ lymphocytes in DKO mice on diet for 18 wk, determined by fluorescence-activated cell sorting (FACS) analysis (n=5). C, Decrease of multipotent progenitor cells (MPPs) and downstream progenitor cells (eg, Sca-1 [stem cells antigen-1]–negative progenitor [LS⁻K], megakaryocyte–erythroid progenitor [MEP], common myeloid progenitor [CMP], and granulocyte–macrophage progenitor [GMP]) in BM of double knockout (DKO) mice after 18 wk of high cholesterol diet (HCD; n=5). D, Increase of splenic hematopoietic and multipotent stem cells in DKO mice after 18 wk of HCD (n=5; Online Figure VII). HPC indicates hematopoietic progenitors cell; HSC, hematopoietic stem cell; Ldlr, low-density lipoprotein receptor; and LSK, lineage^- Sca-1⁺ Kit⁺.