Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 3;121(4):354–367. doi: 10.1161/CIRCRESAHA.116.310529

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 8. — MicroRNA-146a (miR-146a) in the vasculature restrains endothelial cell (EC) activation and atherosclerosis. A, Schematic of lethally irradiated Ldlr^−/− or double knockout (DKO) mice given bone marrow transplantation (BMT) from wild-type (WT BM) donors followed by high cholesterol diet (HCD) for 12 wk. B, Circulating proinflammatory markers, soluble intercellular adhesion molecule-1 (sICAM-1), IL-6 (interleukin-6), and TNF-α (tumor necrosis factor-α), measured by ELISA (n=5–8). C, Circulating cholesterol, high-density lipoprotein (HDL), triglycerides (TG), low-density lipoprotein (LDL) and glucose levels after 12 wk of HCD (n=5). D, Quantification of spleen weight after 12 wk of HCD (n=12–15). E, Fluorescence-activated cell sorting (FACS) analysis of myeloid cells from spleen, BM, and peripheral blood (n=12–15). F, Gene expression in BM cells from BM transplanted animals (n=3–7). G, Percentage of Oil Red-O (ORO) region per aortic arch measured by en face staining (n=11–14). Representative images are shown to the right. Data on EC activation in the aorta are given in Online Figure VIII.