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High-dose VEGF infusion causes IPHs. These axial T2-weighted MR images of animals receiving high-dose VEGF infusion (> 10 μg/ml) revealed severe edema extending along the external capsule (asterisk, A and B), and midline shift (B). A high incidence of IPH with local mass effect (arrowheads) in the juxtacanalicular region was also observed (C). The direction of cannula insertion is indicated by the arrow.
