Table 2. Driver alterations in lung ADC.
| Genetic abnormality | Frequency (%) | |
|---|---|---|
| TCGA data | cBioPortal data | |
| Mutations | ||
| KRAS | 32.2 | 33 |
| EGFR | 11.0 | 14 |
| BRAF | 7.0 | 10 |
| NF1 | 8.3 | 11 |
| MET ex14 | 4.3 | 8 |
| RIT1 | 2.2 | 2 |
| ERBB2 | 1.7 | 1 |
| MAP2K1 | 0.9 | <1 |
| NRAS, HRAS | 0.8 | <1 |
| Amplifications | ||
| MET | 2.2 | 4 |
| ERBB2 | 0.9 | 3 |
| Translocations | ||
| ROS1 | 1.7 | 2 |
| ALK | 1.3 | 3–8 |
| RET | 0.9 | 1 |