Table 3. Impact on nodal upstaging of the number of lymph nodes, lymph node ratio and the number of positive nodal stations resected. Multivariate analysis.

Upstage	Overall # of resected LN	# N1 resected LN	# N2 resected LN	N1 LN ratio	N2 LN ratio	Overall # of positive stations
N0–N1
OR	1.02	1.07	0.99		0.26	3.01
95% CI	1.01–1.04	1.04–1.11	0.96–1.02		0.03–2.44	2.53–3.58
AUC [N]	0.56 [12]	0.63 [6]		0.95 [0.07]		0.94 [1]
P value	0.037	<0.001	0.665		0.237	<0.001
N0–N2
OR	1.03	1.02	1.05			13.81
95% CI	1.01–1.05	0.98–1.06	1.02–1.07			10.2–18.7
AUC [N]	0.59 [11]		0.60 [7]	0.74 [0.06]	0.97 (0.07)	0.98 [2]
P value	0.001	0.282	<0.001			<0.001
N1–N2
OR	1.04	0.99	1.08			3.57
95% CI	0.99–1.09	0.87–1.13	1.02–1.14			2.58–4.93
AUC [N]	0.67 [13]		0.73 [7]	0.86 [0.08]	0.96 [0.08]	0.97 [2]
P value	0.064	0.944	0.008			<0.001

LN, lymph node; CD, complete dissection; SS, systematic sampling; OR, odds ratio; CI, confidence interval; AUC, area under the curve.