Figure 1.

Structural basis of EGFR kinase inhibition by targeted kinase inhibitors. (A) Crystal structures of EGFR kinase in complex with gefitinib, erlotinib and neratinib (PDB IDs: 3UG2, left; 4HJO, middle; 2JIV, right). Compounds are colored in yellow. (B) Overall structure of EGFR kinase in complex with AMP-PNP and allosteric inhibitor, EAI001 (PDB ID: 5D41). EGFR is represented by ribbons. EAI001 and AMP-PNP are displayed as balls-and-sticks and colored yellow and grey, respectively. (C) Detailed view of the ATP and allosteric binding site. Coloring scheme same as 1B. (D) Superposition of the EGFR-EAI001 complex (magenta) against inactive wild type EGFR (PDB ID: 2GS7, green).