Figure 2.

Molecular mechanisms of interplay between cannabinoid system and platelets. (Platelets and megakaryocytes have CB1 and CB2 receptors. Anandamide and 2-AG activate platelets via these receptors. 2-AG has shown to increase release of platelets from megakaryocytes. 2-AG increases expression of glycoprotein IIb-IIIa on activated platelets. Activated platelets and megakaryocytes self-regulate metabolism of 2-AG via FAAH & MAGL pathway. FAAH, fatty acid amide hydrolase, MAGL, monoacylglycerol lipase).