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. 2017 Aug 3;7:82. doi: 10.1186/s13613-017-0302-5

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — a Exceedances of aPTT values >75 s over the course of time in ARDS patients undergoing extracorporeal lung support with either argatroban or heparin as anticoagulant; depicted as relative effect over time; argatroban ****p < 0.0001; heparin p = 0.26. b aPTT values below 50 s over the course of time, depicted as relative effect over time; argatroban and heparin ****p < 0.0001. The relative effect does not represent the measured values of that parameter, but presents (on a scale of 0–1) the treatment effect of the specific group, relative to all groups and therefore to a ‘mean’ treatment effect. Multivariate nonparametric analysis for longitudinal data (MANOVA; Brunner’s analysis)