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. 2017 Aug 4;8:196. doi: 10.1038/s41467-017-00196-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Translational perspectives of employing CTC testing for BCBM patients. Model illustrates clinical implications of BCBM CTC characterization. a Enumeration of BCBM CTCs can be used as a screening method for brain micro-metastasis before they become detectable by MRI. b Serial estimation of BCBM-associated CTCs can be used as a tool to evaluate responses to therapy for BCBM patients, i.e., the reduction of Notch1+ CTCs and/or Ki67+/uPAR+/int-β1+ CTCs, etc