Table 2.
Event rates and efficacy of RTS,S/AS01 vaccine against episodes of Plasmodium falciparum clinical malaria.
| V + 1 Group | V Group | C group | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of individuals | No. of events | PYAR* | Event rate | VE (95% CI) | No. of individuals | No. of events | PYAR* | Event rate | VE (95% CI) | No. of individuals | No. of events | PYAR* | Event rate | |
| Children | ||||||||||||||
| First episode | 247 | 81 | 658.1 | 0.12 | 41.4 (22.4, 55.8) | 263 | 95 | 681.6 | 0.14 | 33.8 (13.4, 49.3) | 250 | 123 | 587.3 | 0.21 |
| All episodes (NB)** | 247 | 143 | 811.4 | 0.18 | 50.7 (32.6, 64.0) | 263 | 219 | 853.4 | 0.26 | 29.0 (4.7, 47.1) | 250 | 300 | 839.9 | 0.36 |
| Infants | ||||||||||||||
| First episode | 255 | 102 | 540.8 | 0.19 | 31.2 (11.3, 46.6) | 257 | 112 | 536.1 | 0.21 | 23.3 (2.8, 40.0) | 272 | 145 | 537.5 | 0.27 |
| All episodes (NB)** | 255 | 263 | 681.7 | 0.39 | 31.2 (8.1, 48.5) | 257 | 304 | 690.2 | 0.44 | 20.9 (4.0, 34.9) | 272 | 420 | 754 | 0.56 |
*PYAR: person-years at risk.
**NB: Negative binomial regression.