Fig. 3.

NPY in the dorsal DG controls background context fear memory. a A schematic of the behavioral paradigms. b Blocking Y1 receptors with BIBP3226 (1.5 pmol per hemisphere; n = 9) during training increases background context conditioning compared to vehicle (n = 11). BIBP3226 treatment does not induce any change, when used in foreground context conditioning (vehicle n = 7; 1.5 pmol BIBP3226 n = 8). No effect is observed on auditory fear memory, as the background context group maintains unchanged cue responding after injection, while the foreground context group continues to show only low levels of freezing. c Localization of guide cannulas in the dorsal DG. d A schematic of the proposed local circuit and site of drug activity. Data are means + s.e.m. Statistical analysis was done with Student’s unpaired t-test. **P < 0.01