Fig. 5.

Chrm1 knock down in HIPP cells increases background context memory. a A schematic of the behavioral paradigm. b Lentiviral vector constructs for the conditional knockdown of Chrm1 and control vector. c Schematic of the proposed circuit. d Representative microscopic images show lentiviral expression of the DsRed marker in NPY⁺ cells (arrows) and NPY⁻ cells of the hilus (asterisks). Scale bar, 10 μm. For an overview refer to Supplementary Fig. 9f. e The knockdown of Chrm1 in SST-Cre^ERT2 mice (n = 8) significantly increases the memory to background context (controls n = 7), while the conditioned response to the CS remains unaffected. Data are means + s.e.m. Statistical analysis was done with Student’s unpaired t-test. *P < 0.05