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. 2017 Aug 3;7:7184. doi: 10.1038/s41598-017-07340-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Killing of A. fumigatus conidia or hyphae is not diminished in PMN from Adamts13 ^−/− mice. Killing of A. fumigatus in vitro by PMN (10⁶ cells/ml) was assessed by modified XTT assay. After 4 h co-culture with conidia (3 × 10³/ml) (A) or conidia (3 × 10³/ml) germinated for 16 h (B), PMN were lysed and conidia were grown for further 16 h. The viability of hyphae was determined using a colorimetric XTT assay. Depicted is the mean plus SD of one representative experiment performed in triplicates out of two. (*) indicates a significant difference (p < 0.05) by one-way ANOVA with Bonferroni’s posttest.