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. 2017 Aug 3;7:7184. doi: 10.1038/s41598-017-07340-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VWF deficiency does not impair inflammatory response in IPA. Inflammatory response to IPA was investigated in wildtype (B6) and Vwf ^−/− mice 24 h after infection. ANC in the blood (A) and in the BALF (B) was measured by an animal blood counter. Shown are the cumulative results of two independent experiments (B6, n = 12; Vwf ^−/−, n = 13). (C) The fungal burden was determined by plating serial dilutions of lung homogenates on Sabouraud 4% glucose agar plates. After 48 h CFU were enumerated. Shown are the cumulative results of two independent experiments (B6, n = 12; Vwf ^−/−, n = 13) plus SD. (D) The albumin concentration of the BAL fluid was quantified by ELISA. The cumulative results of two independent experiments (B6, n = 9; Vwf ^−/−, n = 10) plus SD are depicted. (E) 6 mice of the indicated groups were sacrificed and paraffin sections of the lungs were prepared and stained with H&E. Peribronchial, perivascular and tissue lung scores were determined for the indicated groups by H. B. who was blinded to the experimental treatment groups.