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. 2017 Aug 3;7:7195. doi: 10.1038/s41598-017-06294-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative analysis and comparison of locomotor activity, electrographic activity and neuroluminescence of larvae treated with EKP in combination with/without ASDs. (A) Larval locomotor activity within a 30-min recording normalized to EKP control (set at 100%). Results are shown as mean ± s.e.m. of 12 experiments (recordings of individual larvae) performed in triplicate. (B) Number of epileptic events within a 10-min recording (mean ± s.d.). Number of recordings analyzed were: VHC (n = 35), EKP (n = 58), LMT (n = 13), CBZ (n = 11), PMD (n = 14), ETS (n = 18), LVT (n = 14), TGB (n = 13), PHT (n = 14), RGB (n = 16), VPA (n = 14), OXC (n = 13), ZSM (n = 15), PER (n = 14), TPM (n = 16) and ASP (n = 12). (C) Number of photons emitted within a 30-min recording. Results are expressed as mean ± s.d. of at least 5 independent experiments. For each experiment a group of three larvae was used. All results (A, B, C) were analyzed using one-way ANOVA. Significant differences compared to EKP group are marked with *, **, ***, **** (p ≤ 0.05, p ≤ 0.01, p ≤ 0.001 and p ≤ 0.0001 respectively). (D) Heat map comparison of larval responses against EKP after different ASD treatment as examined by locomotor tracking, electrographic activity recording and neuroluminescence measurements. Data from ASD-treated larvae were normalized against results of the EKP-treated groups.