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. 2017 Aug 3;7:7195. doi: 10.1038/s41598-017-06294-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dimeric models after refinement of the flexible loop (pink) for gad67 (A) and gad65 (D). Close-up on the active site with superimposed EKP (cyan), KPA (purple) and glutamate (blue) for gad67 (B) and gad65 (E). Important amino acids for interaction with the carboxyl-group are labeled. Zoom on the interactions of ligands with residues in the flexible loop in for gad67 (C) and gad65 (F).