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. 2017 Aug 3;7:7188. doi: 10.1038/s41598-017-07694-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The utility of whole heart micro-CT data in mathematical modelling of cardiac depolarisation. Panel (a) shows the conducting tissue segmented from human whole heart micro-CT dataset; sinus node (blue), paranodal area (turquoise), atrioventricular conduction axis (green), the right (red) and left (purple) Purkinje networks. Panel (b) places the segmented conduction system in the anatomical context of the surrounding myocardium. Panel (c) shows a four-chamber view of cardiomyocyte orientation in which the absolute helical angles derived from the CT dataset are coded in colour (see colour map). Panel (d) is an illustrative isochrone map of cardiac depolarisation seeded from the sinus node. The model incorporates the anatomically accurate geometry of the myocardium and the accurate disposition of the conduction system with the electrical properties of these various regions derived from published electrophysiological measurements. IAS- interatrial septum, IVS- interventricular septum, LA- left atrium, LV- left ventricle, RA- right atrium, RV- right ventricle.