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. 2017 Aug 3;7:7211. doi: 10.1038/s41598-017-07830-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SLC39A4 silencing limits metastatic spread in a mouse model of lung cancer. (a) Body weight measurements of tumour-bearing mice. (b) Representative images of mouse lungs 30 d after shSLC39A4 or Ctl A549 cell engraftment. (c) Representative images of H&E staining in lung tissue sections from each group (scale bar, 100 μm). (d) The average number of metastatic tumour nodules in the lungs xenograft mice. E. Immunofluorescence for E-cadherin, FSP-1, and N-cadherin expression in A549 shSLC39A4 or Ctl subcutaneous tumours (scale bar, 100 μm).