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. 2017 Aug 3;7:7211. doi: 10.1038/s41598-017-07830-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of SLC39A4 enhances cisplatin resistance in human NSCLC cells. (a) Correlation of SLC39A4 and CD44 expression, Fisher’s Z = 0.26 (95% CI, 0.19–0.33). (b) Correlation of SLC39A4 and CD133 expression, Fisher’s Z = 0.21 (95% CI, 0.14–0.28). (c,d) Analysis of CD44 and CD133 expression by immunofluorescence (c) and western blotting (d) in shSLC39A4 or Ctl A549 cells (scale bar, 50 μm). (e,f) Cisplatin-induced cell death was monitored in CCK-8 arrays (e) and colony formation assays (f,g). Quantitation of colony formation. (h–j) Body weight (h) and tumour size (i,j) were used to examine cisplatin sensitivity in shSLC39A4 and Ctl A549 tumour-bearing mice.