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. 2017 Aug 3;7:7227. doi: 10.1038/s41598-017-07806-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Blockade of lymphangiogenesis results in delayed resolution of corneal edema and prolonged opacification. Mice were treated with the anti-VEGFR-3 antibody mF4-31C1 (500 µg, intraperitoneally) directly before, on day 3, 6, 9, and 12 after incision injury or equal amounts of PBS. (A–H) In vivo optical coherence tomography scans of the anterior segment measuring central corneal thickness (CCT); (I) Blockade of corneal lymphangiogenesis resulted in delayed regression of CCT. (J–Q) Clinical images of injured corneas; (R) Blockade of lymphangiogenesis resulted in a trend towards higher opacity scores. p.i.: post injury; data are shown as mean + /− SD; n = 5–10 per group per time point; statistical analysis was performed using the unpaired 2-tailed Student’s t test *: p < 0.05.