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. 2017 Feb 22;66(3):191–198. doi: 10.1538/expanim.16-0093

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©2017 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 2. — Normal urothelium and representative pictures of different stages of MNU-induced male rat bladder carcinogenesis in the MNU-only and MNU+O₃ groups with H-E stain (left column) and Ki-67 immunolabeling (right column). A, B) Normal urothelium from the MNU+O₃ group. Arrows show a normal urothelium. C, D) Dysplastic urothelium from the MNU+O₃ group. Arrows show a dysplastic urothelium in cells stained with H-E (C) and Ki-67 (D). E, F) High-grade intraepithelial neoplasia (CIS) from the MNU-only group. Arrows show the CIS area (E) and CIS cells stained with Ki-67 (F). G, H) Low-grade pTa papillary urothelial carcinoma from the MNU+O₃ group. Arrows show the pTa carcinoma area (G) and Ki-67 staining of it (H). I, J) High-grade pT1 papillary urothelial carcinoma from the MNU-only group. Arrows show the pT1 carcinoma area (I) and corresponding Ki-67 staining in the urothelium and submucosa (J). Str, Stroma; Ur, Urothelium.