Table 1. Treatment schedules according to study groups.
Group | Anesthesia | Carcinogen exposure | Used fluids |
---|---|---|---|
Sham (n=6) | Ketamine (90 mg/kg) Xylazine (10 mg/kg) |
None | None |
O3 only (n=15) | Ketamine (90 mg/kg) Xylazine (10mg/kg) |
0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10¶ | 1 ml 25 µg/ml ozonated water twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12 |
MNU only (n=15) | Ketamine (90 mg/kg) Xylazine (10 mg/kg) |
2 mg MNU in 0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10 | 1 ml 0.9% NaCl twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12§ |
MNU+O3 (n=15) | Ketamine (90 mg/kg) Xylazine (10 mg/kg) |
2 mg MNU in 0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10 | 1 ml 25 µg/ml ozonated water twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12 |
¶Vehicle control of MNU treatment. §Vehicle control of O3 treatment.