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. 2017 Feb 22;66(3):191–198. doi: 10.1538/expanim.16-0093

Table 1. Treatment schedules according to study groups.

Group Anesthesia Carcinogen exposure Used fluids
Sham (n=6) Ketamine (90 mg/kg)
Xylazine (10 mg/kg)
None None
O3 only (n=15) Ketamine (90 mg/kg)
Xylazine (10mg/kg)
0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10 1 ml 25 µg/ml ozonated water twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12
MNU only (n=15) Ketamine (90 mg/kg)
Xylazine (10 mg/kg)
2 mg MNU in 0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10 1 ml 0.9% NaCl twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12§
MNU+O3 (n=15) Ketamine (90 mg/kg)
Xylazine (10 mg/kg)
2 mg MNU in 0.2 ml 0.9% NaCl at weeks 0, 2, 4, 6, 8, and 10 1 ml 25 µg/ml ozonated water twice a week at weeks 7, 8, 9, and 10 and three times a week at weeks 11 and 12

Vehicle control of MNU treatment. §Vehicle control of O3 treatment.