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. 2017 Apr 3;36(31):4405–4414. doi: 10.1038/onc.2017.69

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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SPZ1 expression is correlated with liver cancer development. (a) Spz1 was colocalized with Twist1 in liver tumors from Spz1 transgenic mice. Spz1 or mouse IgG, green; Twist1 or rabbit IgG, red. (b) TWIST1 mRNA was overexpressed in the high SPZ1 group compared with the low SPZ1 group. (c) The expression of SPZ1 mRNA in HCC samples correlated with the TWIST1 mRNA expression. (d) Expression of the SPZ1 and TWIST1 proteins in tumor and normal parts from HCC patients. (e) SPZ1 is colocalized with TWIST1 in tumor parts of HCC patients. Green, SPZ1 expression or mouse IgG; red, TWIST1 expression of rabbit IgG; blue; DAPI expression; white, merged. N, nontumor parts; T, tumor parts in a specimen from a patient with HCC.