Table 1. Baseline characteristics of 291 hepatocellular carcinoma (HCC) patients and 243 non-hepatocellular carcinoma patients.
| Group | Non-HCC (n=243) (%) | SPZ1 mRNA (low, n=208)(%) | SPZ1 mRNA (high; n=83)(%) | P-value |
|---|---|---|---|---|
| Age (mean(s.d.)) | 61.6±5.04 | 57.7±2.1 | 59.9±1.4 | 0.6851 |
| Sex | ||||
| Male | 154 (63.37) | 148 (71.15) | 72 (86.75) | 0.6017# |
| Female | 89 (36.63) | 60 (28.85) | 11 (13.25) | |
| GOT (U/l) | ||||
| <40 | 214 (88.07) | 84 (40.38) | 36 (43.37) | 0.8866# |
| 40⩽ <100 | 16 (6.58) | 91 (43.75) | 34 (40.96) | |
| 100⩽ | 13 (5.35) | 33 (15.87) | 13 (15.66) | |
| GPT (U/l) | ||||
| <40 | 216 (88.89) | 82 (39.42) | 34 (40.96) | 0.6587# |
| 40⩽ <100 | 14 (5.76) | 90 (43.27) | 38 (45.78) | |
| 100⩽ | 13 (5.35) | 36 (17.31) | 11 (13.25) | |
| Albumin (mg/dl) | ||||
| <4.5 | 219 (90.12) | 174 (83.65) | 77 (92.77) | 0.0449*# |
| ⩾4.5 | 24 (9.88) | 34 (16.35) | 6 (7.23) | |
| α-Fetoprotein (ng/ml) | ||||
| <20 | 218 (89.71) | 127 (61.06) | 44 (53.01) | 0.2635# |
| ⩾20 | 25 (10.29) | 81 (38.94) | 39 (46.99) | |
| Bilit | ||||
| 1.5< | 132 (54.32) | 168 (80.77) | 72 (86.75) | 0.3695# |
| ⩾1.5 | 111 (45.68) | 40 (19.23) | 11 (13.25) | |
| Lymphovascular invasion | ||||
| No | 243 (100) | 154 (74.04) | 47 (56.63) | 0.0058*# |
| Yes | 0 | 54 (25.96) | 36 (43.37) | |
| Size(cm) | <0.001* | |||
| <2.5 | 79(37.98) | 12(14.46) | ||
| 2.5⩽ | 129(62.02) | 71(85.54) | ||
| Number of tumors | <0.001* | |||
| 1 | 172 (82.69) | 48 (57.83) | ||
| 1< | 36 (17.31) | 35 (42.17) | ||
| Modified TNM | <0.001* | |||
| I | 146 (70.19) | 31 (37.35) | ||
| II | 51 (24.52) | 29 (34.94) | ||
| III (IIIA and IIIB) | 11 (5.29) | 23 (27.71) | ||
Abbreviations: GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; HCC, hepatocarcinoma cells.
#P-values were calculated by Fisher exact test.
High SPZ1 mRNA expression patients: SPZ1 mRNA expression in tumor part were higher three point five folds (>3.5 folds) than adjacent normal part liver tissue.
Low SPZ1 mRNA expression patients: SPZ1 mRNA expression in tumor part were lesser three folds (<3.5 folds) than adjacent normal part liver tissue. (cut point by survival ROC curve).
*P<0.05.
Patients: 291HCC patients from two medical centers [Chung Ho Memorial Hospital (257HCC) and Changhua Christian Hospital (34 HCC)] were enrolled into the SPZ1 cohort study from July 2005 to July 2014.