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. 2017 Aug 4;8:510. doi: 10.3389/fphar.2017.00510

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Copyright © 2017 Zhao, Li, Zhao, Cheng, Yang, Fang, Xie, Liu, Chen, Ouyang and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Causes of polycations' immunogenicity: the recognition of carried gene sequences and polycations, ROS produced by polycations, and the impact on immune cells are the main causes of polycations' immunogenicity.