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Effect of the systemic administration of cocaine [20 mg/kg i.p.; (A)], amphetamine [10 mg/kg i.p.; (B)], JWH-018 [0.3 mg/kg i.p.; (C)], and AKB48 [0.3 mg/kg i.p.; (D)] on dopamine (DA) transmission in the nucleus accumbens (NAc) shell of mice. Results are expressed as mean ± SEM of change in DA extracellular levels expressed as the percentage of basal values. *p < 0.05, ***p < 0.001 versus vehicle (NAc shell n = 13) (two-way ANOVA, Tukey’s HSD post hoc).
