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Affinity values of GBR 12783, cocaine, amphetamine, JWH-018, and AKB48 to DAT obtained from [3H]-WIN 35,428 competition binding experiments in human CHO membranes transfected with DAT and in mouse striatal synaptosomes.
| Compounds | hDAT-CHO membranes Ki (nM) | Mouse striatal synaptosomes Ki (nM) |
|---|---|---|
| GBR 12783 | 1.93 ± 0.14 | 1.72 ± 0.11 |
| Cocaine | 174 ± 13 | 193 ± 16 |
| Amphetamine | 554 ± 47 | 622 ± 53 |
| JWH-018 | 7,183 ± 528 | >10,000 |
| AKB48 | 4,588 ± 326 | >10,000 |
Data are expressed as mean ± SEM.
