Table 2.

Results of MIC obtained with fluoroquinolones and mutations identified in gyrA, gyrB, parC, and parE among S. epidermidis strains isolated from the infected eye and healthy conjunctiva.

Strain designation (no. of strains) from		MIC of fluoroquinolones (mg/L)				QRDR showing mutation in genes for
Infected eye	Healthy Conjunctiva	MXF	GAT	OFX	CIP	gyrA	gyrB	parC	parE
409, 1520, 1429 (3)	N69OD (1)	4	4	32	>64	S84 → F	NIL	S80 → F	NIL
–	N63OD, N95OS (2)	1	2	8	4
1362 (1)	–	0.5	2	16	>64
1497 (1)	–	>64	>64	>64	32
1558 (1)	–	2	16	16	32
1606 (1)	–	2	32	2	2
–	N64OS (1)	2	2	16	16
108, 1121, 1184, 1515 (4)	–	4	4	32	>64	S84 → F	NIL	S80 → F	NIL
								D84 → C*
866, 1001, 1386 (3)	–	4	4	32	>64	S84 → Y	NIL	S80 → Y	NIL
–	N80OS (1)	>64	>64	>64	>64
–	N89OS (1)	2	2	8	4
1142W (1)	–	1	1	2	32	NIL	NIL	NIL	N404 → S
–	N78OD (1)	2	4	8	4
1502 (1)	N79OS (1)	4	8	>64	>64	S84 → Y		S80 → F
–	N3OD (1)	>64	>64	>64	>64	S84 → F	NIL	S80 → Y	NIL
–	N67OS (1)	2	4	16	16
–	N74OS, N101OD (2)	2	2	16	16	S84 → F	NIL	NIL	NIL
–	N91OD, N93OSW (2)	0.25	0.25	1	1	NIL	NIL	D84 → A	NIL
1033 (1)	–	2	1	32	>64	S84 → F	NIL	S80 → F	NIL
								V82 → L*
								D84 → C*
1122 (1)	–	>64	>64	>64	8	S84 → F	NIL	NIL	N404 → S
1123 (1)	–	1	2	16	1	S84 → F	NIL	S80 → F	N404 → S
1056 (1)	–	2	2	>64	>64	S84 → F	NIL	D84 → Y	N404 → S
1150 (1)	–	4	4	32	8	S84 → F	NIL	D84 → Y	N404 → S
–	N96OD (1)	32	32	>64	64	S84 → Y	NIL	NIL	NIL
–	N98OD (1)	0.125	0.125	0.25	0.25	NIL	NIL	S80 → F	NIL
1163, 1528 (2)	N1OD, N5OD, N6OS, N16OD, N18OD, N41OD, N46OD, N47OD, N52OD, N53OS, N81OD, N85OD, N94OD (13)	0.125	0.125	0.5	0.25	NIL	NIL	NIL	NIL

MXF, Moxifloxacin; GAT, Gatifloxacin; OFX, Ofloxacin; CIP, Ciprofloxacin. Resistant: Bold; Intermediate: Bold italic; Sensitive: Normal.

^*Novel mutations found in this study.