Table 1. Histopathologic Concordance Diagnoses and PLA Results of 60 Cases Clinically Suggestive of Melanoma.
| Histopathologic Concordance Diagnosis (No. of Lesions) | LINC00518 and PRAME Detected | LINC00518 Only Detected | PRAME Only Detected | Median PLA Scorea |
|---|---|---|---|---|
| Melanoma (8) | ||||
| Invasive (6) | 5 | 1 | 0 | 90 |
| In situ (2) | 2 | 0 | 0 | 90 |
| Nonmelanoma (52) | ||||
| Atypical nevus (42) | 1 | 5 | 0 | 41 |
| Conventional nevus (2) | 0 | 0 | 0 | 5 |
| Other (8)b | 0 | 0 | 0 | 16 |
Abbreviations: LINC00518, long intergenic non–protein coding RNA 518 gene; PLA, pigmented lesion assay; PRAME, preferentially expressed antigen in melanoma gene.
a
Scores range from 0 to 100, with higher scores indicating malignant disease.
b
Includes 5 lentigines and 3 keratoses.