Table 3. Multivariable Regression for All-Cause Mortality by Age Group and for Coronary Heart Disease (CHD) Events by Age Group.
Variable | 65-74 y | ≥75 y | Total | |||
---|---|---|---|---|---|---|
HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
Multivariable Regression for All-Cause Mortality by Age Group | ||||||
Pravastatin | 1.05 (0.82-1.33) | .72 | 1.36 (0.98-1.89) | .06 | 1.15 (0.94-1.39) | .17 |
Age | 1.06 (1.01-1.10) | .01 | 1.11 (1.06-1.15) | <.01 | 1.08 (1.06-1.10) | <.01 |
Female | 0.83 (0.65-1.07) | .16 | 0.53 (0.38-0.74) | <.01 | 0.71 (0.58-0.87) | <.01 |
Systolic blood pressure | 1.01 (1.00-1.02) | .01 | 1.01 (1.00-1.02) | .11 | 1.01 (1.00-1.02) | <.01 |
Diastolic blood pressure | 0.99 (0.98-1.01) | .37 | 1.00 (0.98-1.02) | .90 | 1.00 (0.99-1.01) | .52 |
Aspirin use | 1.03 (0.77-1.36) | .86 | 0.86 (0.59-1.24) | .42 | 0.97 (0.77-1.21) | .78 |
Body mass index | 1.00 (0.98-1.02) | .90 | 0.99 (0.95-1.02) | .44 | 1.00 (0.98-1.02) | .98 |
Black race/ethnicity | 1.04 (0.81-1.33) | .76 | 1.15 (0.82-1.60) | .41 | 1.08 (0.88-1.31) | .47 |
Current cigarette smoker | 1.90 (1.43-2.53) | <.01 | 1.49 (0.91-2.45) | .11 | 1.75 (1.37-2.24) | <.01 |
Type 2 diabetes | 1.74 (1.32-2.29) | <.01 | 1.66 (1.17-2.35) | <.01 | 1.66 (1.34-2.05) | <.01 |
Multivariable Regression for CHD Events by Age Group | ||||||
Pravastatin | 0.85 (0.63-1.16) | .31 | 0.70 (0.42-1.15) | .16 | 0.80 (0.62-1.04) | .09 |
Age | 1.02 (0.96-1.08) | .48 | 1.05 (0.99-1.12) | .13 | 1.03 (1.01-1.06) | .01 |
Female | 0.77 (0.56-1.06) | .11 | 0.46 (0.27-0.77) | <.01 | 0.65 (0.50-0.86) | <.01 |
Systolic blood pressure | 1.01 (1.00-1.02) | .06 | 1.01 (0.99-1.02) | .51 | 1.01 (1.00-1.02) | .06 |
Diastolic blood pressure | 1.00 (0.98-1.02) | .75 | 1.00 (0.98-1.03) | .86 | 1.00 (0.98-1.01) | .83 |
Aspirin use | 1.05 (0.73-1.49) | .80 | 1.52 (0.92-2.51) | .11 | 1.21 (0.91-1.61) | .20 |
Body mass index | 1.00 (0.97-1.02) | .75 | 0.95 (0.90-1.01) | .10 | 0.99 (0.96-1.01) | .29 |
Black race/ethnicity | 0.93 (0.68-1.28) | .66 | 0.79 (0.46-1.35) | .39 | 0.89 (0.68-1.17) | .40 |
Current cigarette smoker | 1.49 (1.02-2.17) | .04 | 0.95 (0.41-2.16) | .89 | 1.31 (0.93-1.84) | .13 |
Type 2 diabetes | 2.13 (1.49-3.04) | <.01 | 1.30 (0.78-2.18) | .32 | 1.80 (1.35-2.40) | <.01 |
Abbreviation: HR, hazard ratio for pravastatin sodium vs usual care.