Table 1:

Summary of method features for computational drug combination prediction tools used in this analysis.

Drug Combination Prediction Method	CMap data	LINCS data	Pathway enrichment of query genes	Network mining of query genes	Drug target information	# of testable validation drugs
SynGeNet		✔		✔	✔	13
CDA	✔		✔			8
DPS	✔	✔				28