Figure 5.

Conservation of surface-exposed residues among human 14-3-3 isoforms. (a) Residue conservation of the seven human isoforms of 14-3-3 determined with ConSurf⁴⁷ after amino acid sequence alignment of the seven human isoforms of 14-3-3 performed with ClustalOmega.⁴⁸ Corresponding protein entries (UniProt) P62258 for 14-3-3ε, P31947 for 14-3-3σ, Q04917 for 14-3-3η, P61981 for 14-3-3γ, P27348 for 14-3-3τ, P31946 for 14-3-3β, and P63104 for 14-3-3ζ. The TAZpS89 peptide is shown as green sticks. (b) The positions of the binding pockets of the fragments are indicated by yellow circles.