Table 2. KRAS and GNAS mutation analysis for pancreatic duct fluid and duodenal fluid.
|
KRAS |
GNAS |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pancreatic duct fluid | Duodenal fluid | Pancreatic duct fluid |
Duodenal fluid |
|||||||||
| Patient | CAPS | Interval | Color of duodenal fluid | Ratio of duodenal fluid to pancreatic duct fluid DNA concentration | Mutation (%) | Mutation type (estimated %) | Mutation (%) | Mutation type (estimated %) | Mutation (%) | Mutation type (estimated %) | Mutation (%) | Mutation type (estimated %) |
| 1 | 2 | 3 days | Serous-pink | 25.4 | 0 | 0 | 0 | |||||
| 2 | 2 | 3 days | Green | 1.4 | 0 | 0 | 0 | |||||
| 3 | 2 | 3 days | Serous-pink | 1.0 | 0 | 0 | 0 | |||||
| 4 | 2 | 3 days | Green | 0.4 | 0 | 0 | 0.22 | R201C (50%), R201H (50%) | 0 | |||
| 5 | 2 | 3 days | Serous | 0.3 | 0 | 0 | 0 | |||||
| 6 | 2 | 3 days | Serous-pink | 0.8 | 0 | 0 | 0 | |||||
| 7 | 3 | Same day | Green | 1.1 | 0 | 0 | 0 | |||||
| 8 | 2 | 3 days | Serous-pink | 7.0 | 0.22 | G12R (100%) | 0 | 0 | ||||
| 9 | 2 | 3 days | Serous | 0.2 | 0.22 | G12D (100%) | 0.11 | G12D (100%) | 0 | |||
| 10 | 2 | 3 days | Serous | 5.7 | 0.22 | G12D (50%), G12R (50%) | 0 | 0.11 | R201H (100%) | 0 | ||
| 11 | 4 | Same day | Serous | 0.5 | 0.22 | G13D (100%) | 0 | 0 | ||||
| 12 | 2 | 3 days | Pink | 8.2 | 0.33 | G12D (66%), G12V (33%) | 0 | 0 | ||||
| 13 | 2 | 3 days | Green | 2.0 | 0.33 | G12S (33%), G12R (66%) | 0.11 | G12R (100%) | 0 | |||
| 14 | 2 | 3 days | Serous-pink | 3.9 | 0.33 | G12D (66%), G12V (33%) | 0.11 | G12V (100%) | 0 | |||
| 15 | 2 | 3 days | Serous-pink | 21.7 | 0.56 | G12D (40%), G12V (40%),G12C (20%) | 0.17 | G12C (100%) | 0 | |||
| 16 | 2 | 3 days | Green | 1.1 | 0.67 | G12D (83%), G12R (17%) | 0.11 | G12D (100%) | 0.33 | R201C (100%) | 0 | |
| 17 | 2 | 3 days | Serous-pink | 2.1 | 0.89 | G12D (100%) | 0 | 0.33 | R201H (100%) | 0 | ||
| 18 | 4 | Same day | Green | 2.0 | 0.89 | G12V (56%), G12A (22%), G12R (22%) | 0.11 | G12R (100%) | 0 | |||
| 19 | 2 | 3 days | Serous-pink | 7.8 | 1.00 | G12D (36%), G12V (27%), G12R (36%) | 0 | 0 | ||||
| 20 | 2 | 2 months | Serous | 1.4 | 1.22 | G12D (100%) | 0.11 | G12D (100%) | 0.11 | R201H (100%) | 0.11 | R201H (100%) |
| 21 | 2 | 3 days | Green | 0.8 | 1.44 | G12D (81%), G12R (18%) | 0.22 | G12R (100%) | 0.78 | R201C (100%) | 0.06 | R201C (100%) |
| 22 | 4 | Same day | Serous | 10.3 | 1.67 | G12D (10%), G12V (80%), G12R (10%) | 0.22 | G12D (50%), G12R (50%) | 0.11 | R201C (100%) | 0 | |
| 23 | 2 | 3 days | Serous-pink | 2.4 | 1.89 | G12D (40%), G12R (60%) | 0.11 | G12D (100%) | 0.11 | R201H (100%) | 0 | |
| 24 | 2 | 3 days | Serous | 2.1 | 1.89 | G12D (10%), G12V (50%), G12R (40%) | 0.11 | G12R (100%) | 0 | |||
| 25 | 2 | 3 days | Pink | 1.0 | 2.00 | G12D (50%), G12V (10%), G12R (40%) | 0.11 | G12R (100%) | 0.33 | R201H (100%) | 0 | |
| 26 | 2 | 3 days | Serous-pink | 0.3 | 2.44 | G12V (30%), G12R (70%) | 0.67 | G12R (100%) | 0 | |||
| 27 | 2 | 3 days | Serous | 1.2 | 2.56 | G12D (10%), G12V (70%), G12R (10%), G12A (10%) | 0.22 | G12V (100%) | 0 | |||
| 28 | 2 | 3 days | Serous-pink | 3.2 | 2.56 | G12D (20%), G12V (80%) | 0.06 | G12V (100%) | 0 | |||
| 29 | 2 | 3 days | Serous-pink | 1.4 | 4.11 | G12D (43%), G12V (14%), G12R (43%) | 0.22 | G12D (100%) | 0 | |||
| 30 | 2 | 3 days | Green | 1.7 | 4.78 | G12D (38%), G12V (42%), G12R (20%) | 0.11 | G12R (100%) | 0.11 | R201C (100%) | 0 | |
| 31 | 2 | 3 months | Green | 13.5 | 5.56 | G12D (29%), G12V (29%), G12R (41%) | 0.22 | G12D (50%), G12R (50%) | 0 | |||
| 32 | 2 | 3 days | Green | 5.8 | 6.67 | G12D (47%), G12V (42%), G12R (11%) | 0.11 | G12D (100%) | 3.67 | R201C (67%), R201H (33%) | 0.22 | R201C (100%) |
| 33 | 2 | 3 days | Serous | 6.1 | 7.33 | G12D (8%), G12V (8%), G12R (83%) | 0.11 | G12R (100%) | 0.11 | R201H (100%) | 0 | |
| 34 | 4 | Same day | Serous | 0.1 | 7.44 | G12D (24%), G12V (18%), G12R (58%) | 7.11 | G12D (30%), G12V (12%), G12R (58%) | 0.11 | R201C (100%) | 0.22 | R201C (100%) |
| 35 | 2 | 4 months | Serous | 0.8 | 8.00 | G12D (47%), G12V (53%) | 0.11 | G12D (100%) | 0 | |||
| 36 | 2 | 3 days | Unknown | 6.9 | 8.56 | G12D (90%), G12V (9%) | 0.22 | G12D (50%), G12R (50%) | 0 | |||
Bold and underlined mutation types matched pancreatic duct fluid with duodenal fluid.